News

May 12, 2016May 12, 2016

Bim Marker May Predict Success for Melanoma Immunotherapy

News

Mayo Clinic researchers have discovered that a potential marker called Bim may be a clue to overall survival in patients undergoing anti-PD-1 therapy. The team believes that measuring the Bim ... Read more

May 10, 2016May 10, 2016

New Compound Successfully Targets Mutation Linked to Melanoma and Lymphoma

Melanoma, News

A study has shown that a new compound, JQEZ5, may help to treat certain types of cancers, particularly lymphoma and melanoma. The article, published in the journal Nature Medicine, is titled “An oncogenic Ezh2 mutation induces ... Read more

May 5, 2016May 5, 2016

Gene Expression Test of Metastasis Risk in Melanoma Patients Validated in Independent Study

Melanoma, News

An independent study of Castle Biosciences’ DecisionDx-Melanoma gene expression profile test, used to identify the risk of metastasis in patients with stage 1 or 2 cutaneous melanoma, verified the accuracy ... Read more

April 28, 2016April 28, 2016

Nivolumab (Opdivo) Seen in Clinical Trial to Improve Long-Term Survival in Advanced Melanoma Patients

News

Bristol-Myers Squibb’s nivolumab (Opdivo) has shown a robust five-year overall survival (OS) rate of 34 percent in heavily pretreated patients with metastatic melanoma, who had not received prior ipilimumab (Yervoy) therapy. The ... Read more

April 26, 2016April 26, 2016

Aging Influences Melanoma Response to Therapies, but Antioxidants Could Provide Answer

News

The risk of developing cancer increases with age as accumulated damage to the cells and chronic inflammation arise over time. In a new study published in Nature, an international team of ... Read more

April 21, 2016April 21, 2016

Melanoma Study in Mice Finds a Macrophage Group with Unusual Ability to Protect Against Cancer Progression

News

Massachusetts General Hospital researchers working in a mouse model of melanoma found that a specific type of immune cell — called subcapsular sinus (SCS) macrophages — forms a protective coat around lymph ... Read more

April 19, 2016April 19, 2016

Melanoma Research Alliance to Benefit from May 24 Fundraiser Sponsored by Leverage Finance Community

News

The Melanoma Research Alliance (MRA) will be the beneficiary of a May 24 fundraiser by the leveraged finance community to support continued research into better treatments and, possibly, a cure for the skin ... Read more

April 12, 2016April 12, 2016

Targeted Checkpoint Blocking Therapies Not Yet an Effective Melanoma Treatment, Cancer Expert Says

News

In a talk at the recent HemOnc Today’s Melanoma and Cutaneous Malignancies meeting, Christian Blank, group leader of the division of immunology at Netherlands Cancer Institute, presented his views of checkpoint blocking therapies. ... Read more

April 5, 2016April 7, 2016

Advanced Melanoma Combo Treatment, Opdivo/Yervoy, Gets a Positive Opinion from CHMP

News

The Committee for Medicinal Products for Human Use (CHMP) has released a positive opinion supporting the approval of Bristol-Myers Squibb‘s Opdivo (nivolumab), combined with Yervoy (ipilimumab), to treat adult patients with advanced (unresectable or metastatic) melanoma. The CHMP opinion also added a statement to ... Read more

March 31, 2016March 31, 2016

Immunocore Recruits 1st Uveal Melanoma Patient in Phase I Trial of Biological Drug, IMCgp100

News

Immunocore announced it has recruited the first patient for its Phase I monotherapy clinical trial of IMCgp100, its lead product candidate to treat uveal melanoma. Uveal melanoma is a cancer (melanoma) of the eye involving the iris, ciliary body, ... Read more

March 29, 2016March 29, 2016

Melanoma Study in Mice Uses a Microneedle Patch System to Effectively Deliver Immunotherapy

News

Despite advances in melanoma treatment, mainly as a consequence of anti-PD-1 (aPD1) immunotherapy, the approach still needs improvement. Now, North Carolina State University and the University of North Carolina at Chapel Hill ... Read more

March 24, 2016March 24, 2016

Multiple Gene Mutations Predict Recurrence in Malignant Melanoma and Clinical Outcomes, Study Suggests

News

In a new study, researchers investigated whether molecular profiling could predict clinical outcomes, and found that patients with primary malignant melanoma are at a higher risk of recurrent disease if they present ... Read more

March 22, 2016March 22, 2016

Melanoma Cells’ Transition from Benign to Malignant Mapped, and Reversed, in Yale Lab

News

The mechanism by which benign melanoma cells change into malignant ones is greatly affected by the cells’ stiffness, as determined by the specific balance of two signaling pathways — which, in turn, can ... Read more

March 17, 2016March 17, 2016

myPath Melanoma Test Shows 90% Accuracy in 2nd Trial, Company Reports at USCAP 2016

News

Myriad Genetics, Inc., recently released positive data from a second and pivotal clinical validation trial of its myPath Melanoma test in a poster presentation at the 2016 USCAP Annual Meeting in Seattle, Washington. “There is significant emotional distress associated ... Read more

March 15, 2016March 15, 2016

Study Links Increased Risk of Melanoma to Use of Sildenafil

News

Researchers have found that sildenafil — a drug used to treat erectile dysfunction and pulmonary hypertension — is linked to an increased risk of melanoma by promoting cGMP-cGKI signaling cascade. The ... Read more

March 10, 2016March 10, 2016

Researchers Identify Gene Linked to Growth of Melanoma, Possibly Leading to New Treatments

News

Yale researchers have discovered a gene associated with melanoma and its growth, which could pave the way for new therapeutics. The study, “DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 ... Read more

March 8, 2016May 17, 2016

Blood Test May Reveal Early Signs of Skin Cancer Relapse

News

A recent study published in Cancer Discovery has revealed that a blood test may give early alerts of a relapse in advanced melanoma patients. The study, titled “Application of sequencing, liquid biopsies and patient-derived xenografts ... Read more

March 3, 2016March 3, 2016

Melanomas Often Diagnosed in People with a Limited Number of Skin Moles, Study Reports

News

Nevi, or skin moles, are strongly associated with melanoma. But recent findings revealed that most melanoma patients have few and no atypical moles, and thick melanomas in people under age 60 are more often found in ... Read more

March 1, 2016March 1, 2016

New Malignant Melanoma Target Discovered by Yale Researchers

News

Researchers at Yale Cancer Center have discovered a gene that has a dramatic impact on the growth of melanoma. Their observations, titled ”DNMT3b Modulates Melanoma Growth by Controlling Levels of ... Read more

February 25, 2016February 25, 2016

Study Finds Link Between Melanoma and Parkinson’s Disease, Researchers Say

News

Recent findings indicate there may be a link between Parkinson’s disease and melanoma, with family history and common genetic susceptibility as possible causes. The review is published in the journal Dermatologic Surgery ... Read more